Bioactive Compounds in Osteoarthritis: Molecular Mechanisms and Therapeutic Roles

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Review

. 2024 Oct 30;25(21):11656.


doi: 10.3390/ijms252111656.

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Review

Ahmed Maouche et al.


Int J Mol Sci.


.

Abstract

Osteoarthritis (OA) is the most common and debilitating form of arthritis. Current therapies focus on pain relief and efforts to slow disease progression through a combination of drug and non-drug treatments. Bioactive compounds derived from plants show significant promise due to their anti-inflammatory, antioxidant, and tissue-protective properties. These natural compounds can help regulate the inflammatory processes and metabolic pathways involved in OA, thereby alleviating symptoms and potentially slowing disease progression. Investigating the efficacy of these natural agents in treating osteoarthritis addresses a growing demand for natural health solutions and creates new opportunities for managing this increasingly prevalent age-related condition. The aim of this review is to provide an overview of the use of some bioactive compounds from plants in modulating the progression of osteoarthritis and alleviating associated pain.


Keywords:

Boswellia serrata; Harpagophytum procumbens; Zingiber officinale; avocado/soybean unsaponifiables; bioactive compounds; curcumin; inflammation; joint pain; osteoarthritis; plant extracts; resveratrol; tea extracts.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Yu D., Huang X., Mamas M.A., Wilkie R. Persistent High Prevalence of Modifiable Cardiovascular Risk Factors Among Patients with Osteoarthritis in the UK in 1992–2017. RMD Open. 2023;9:e003298. doi: 10.1136/rmdopen-2023-003298.

      –

      DOI

      –

      PMC

      –

      PubMed

    1. Lee Y.T., Yunus M.H.M., Ugusman A., Yazid M.D. Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis. Antioxidants. 2022;11:1722. doi: 10.3390/antiox11091722.

      –

      DOI

      –

      PMC

      –

      PubMed

    1. Terkawi M.A., Ebata T., Yokota S., Takahashi D., Endo T., Matsumae G., Shimizu T., Kadoya K., Iwasaki N. Low-Grade Inflammation in the Pathogenesis of Osteoarthritis: Cellular and Molecular Mechanisms and Strategies for Future Therapeutic Intervention. Biomedicines. 2022;10:1109. doi: 10.3390/biomedicines10051109.

      –

      DOI

      –

      PMC

      –

      PubMed

    1. Berenbaum F. Osteoarthritis as an Inflammatory Disease (Osteoarthritis Is Not Osteoarthrosis!) Osteoarthr. Cartil. 2013;21:16–21. doi: 10.1016/j.joca.2012.11.012.

      –

      DOI

      –

      PubMed

    1. Attur M., Belitskaya-Lévy I., Oh C., Krasnokutsky S., Greenberg J., Samuels J., Smiles S., Lee S., Patel J., Al-Mussawir H., et al. Increased Interleukin-1β Gene Expression in Peripheral Blood Leukocytes Is Associated with Increased Pain and Predicts Risk for Progression of Symptomatic Knee Osteoarthritis. Arthritis Rheum. 2011;63:1908–1917. doi: 10.1002/art.30360.

      –

      DOI

      –

      PMC

      –

      PubMed

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